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Centre of Aging in Musculoskeletal Degeneration & Regeneration

The Centre is funded by the Research Grants Council, Hong Kong SAR, Areas of Excellence (AoE) Scheme (AoE/M-402/20: Aging, Skeletal Degeneration and Regeneration).

 

This project addresses the challenges of an aging global population, particularly in Hong Kong, where the elderly population is projected to rise from 15% in 2014 to 36% by 2064. This demographic shift is accompanied by a high incidence of age-associated osteoporosis and bone fractures, which occur globally at a rate of one every three seconds, imposing significant socio-economic and financial burdens.

Our Mission

To facilitate the clinical translation of innovative treatments for musculoskeletal disorders associated with aging. It focuses on multidisciplinary research to advance skeletal regeneration in the context of bone metabolic disorders and fragility injuries, with a specific interest in bioactive and biodegradable implant materials for temporal fixation and skeletal regeneration.

FROM BENCH TO BEDSIDE: A Paradigm for Translation of Class III Orthopaedic Implants

Our Services

Sub-Projects

The “Aging, Skeletal Degeneration and Regeneration” program encompasses nine interconnected sub-projects that span fundamental biology, biomaterials innovation, degenerative disease mechanisms, and translational sciences.

 

Together, they form a comprehensive research framework aimed at understanding age-related musculoskeletal decline and advancing next-generation strategies for skeletal repair, regeneration, and clinical implementation.

Age‑Related Musculoskeletal Degeneration

Research addressing the mechanisms and progression of musculoskeletal decline associated with aging, with the goal of preserving long-term function and mobility.

Fracture Healing & Bone Regeneration

Studies focusing on the biological and biomechanical processes of fracture repair and strategies to enhance bone regeneration.

Cellular & Molecular Mechanisms

Investigations that elucidate the cellular behaviors and molecular pathways underlying musculoskeletal development, pathology, and repair.

Biomaterials & Implant Design

Work exploring advanced biomaterials and implant engineering to improve safety, performance, and integration in orthopaedic applications.

Cartilage Repair & Osteoarthritis

Research examining cartilage injury, degenerative joint disease, and interventions aimed at restoring joint structure and function.

Spine & Intervertebral Disc Regeneration

Studies on spinal disorders and disc degeneration, with an emphasis on therapeutic strategies to restore structural integrity and biomechanical function.

Our Services

Neuro‑
Musculoskeletal Interface

Investigations focusing on the interactions between the nervous system and musculoskeletal tissues, particularly in injury, regeneration, and functional restoration.

Guidelines & Standards

Literature that informs the development of musculoskeletal-related guidelines and standards derived from this project’s research outcomes.

Clinical Translation & Regulatory Science

Work bridging laboratory innovations to clinical implementation, covering safety evaluation, regulatory pathways, and translational methodologies.

Our Team Member &
Collaborator Institutions

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Contact Us

Address: Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Hong Kong SAR

Tel. +852 3505 3308

Copyright © 2025. All Rights Reserved. RGC-AoE Centre of Aging in Musculoskeletal Degeneration and Regeneration, the Chinese University of Hong Kong.. 

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