top of page

Publication List

The “Aging, Skeletal Degeneration and Regeneration” program encompasses nine interconnected subthemes that span fundamental biology, biomaterials innovation, degenerative disease mechanisms, and translational sciences.

 

Together, these subthemes form a comprehensive research framework aimed at understanding age-related musculoskeletal decline and advancing next-generation strategies for skeletal repair, regeneration, and clinical implementation.

  • Facebook
  • Twitter
  • Linkedin
Cover Story

01. 
Age-Related Musculoskeletal Degeneration

Research addressing the mechanisms and progression of musculoskeletal decline associated with aging, with the goal of preserving long-term function and mobility.

伸出援手

  1. Long, Y.-F., Cui, C., Wang, Q., Xu, Z., Chow, S.-H., Zhang, N., Wong, R., Chui, E.-S., Schoenmehl, R., Brochhausen, C., Rubin, C., Li, G., Qin, L., Yang, D.-Z.* and Cheung, W.-H*., Low-Magnitude High-Frequency Vibration Attenuates Sarcopenia by Modulating Mitochondrial Quality Control via Inhibiting miR-378. Journal of Cachexia, Sarcopenia and Muscle, 2025; 16: e13740. 🔗

  2. Chen, Z., Xu, J., Hu, P., Du, W., Chen, J., Zhang, X., Zhou, W., Gao, J., Zhang, Y., Dai, B., Nie, G., Hu, J., Zhou, L., Xu, S., Chan, H. C., Cheung, W. H., Ruan, Y. C.* & Qin, L*. Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis. J Cachexia Sarcopenia Muscle. 2025; 16, e13708. 🔗

  3. Cheng KYK, Chow SKH, Hung VWY, Tsang ZTL, Yip BHK, Wong RMY, Zhang N, Qin L, Law SW, Cheung WH*. Identification of osteosarcopenia by high-resolution peripheral quantitative computed tomography. J Pers Med. 2024; 14(9):935. 🔗

  4. Bao Z, Cui C, Liu C, Long YF, Wong RMY, Chai S, Qin L, Rubin C, Yip BHK, Xu Z, Jiang Q, Chow SKH, Cheung WH*. Prevention of age-related neuromuscular junction degeneration in sarcopenia by low-magnitude high-frequency vibration. Aging Cell. 2024; 23:e14156. 🔗

  5. Wang Q, Cui C, Zhang N, Lin W, Chai S, Chow SKH, Wong RMY, Hu Y, Law SW, Cheung WH*. Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review. J Orthop Translat. 2024; 46:91-102.  🔗

  6. Hou Y, Gao W, Lui KO*. A hidden role of Th17 cells in doxorubicin-induced cardiac ferroptosis. Cardiovascular Research. 2024; 120:1989-1991. 🔗

  7. Mi B, Xiong Y, Knoedler S, Alfershofer M, Panayi A, Wang H, Lin S*, Li G*, Liu G*. Ageing-related bone and immunity changes: Insights into the complex interplay between the skeleton and the immune system. Bone Research. 2024;12:42.  🔗

  8. Long YF, Chow SKH, Cui C, Wong RMY, Zhang N, Qin L, Law SW, Cheung WH*. Does exercise influence skeletal muscle by modulating mitochondrial functions via regulating MicroRNAs? A systematic review. Ageing Res Rev. 2023; 91:102048. 🔗

  9. Long YF, Chow SKH, Cui C, Wong RMY, Qin L, Law SW, Cheung WH*. Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review. J Orthop Translat. 2022; 35:37-52. 🔗

  10. Cui C, Bao Z, Chow SKH, Wong RMY, Welch A, Qin L, Cheung WH*. Coapplication of magnesium supplementation and vibration modulate macrophage polarization to attenuate sarcopenic muscle atrophy through PI3K/Akt/mTOR signaling pathway. Int J Mol Sci. 2022; 23:12944. 🔗

  11. Li MCM, Chow SKH, Wong RMY, Chen B, Cheng JCY, Qin L, Cheung WH*. Osteocyte-specific dentin matrix protein 1: the role of mineralization regulation in low-magnitude high-frequency vibration enhanced osteoporotic fracture healing. Bone Joint Res. 2022; 11:465-476. 🔗

图片1.png

02. 
Fracture Healing & Bone Regeneration

Studies focusing on the biological and biomechanical processes of fracture repair and strategies to enhance bone regeneration.

  1. ​Y An, H Zhang, S Zhang, Y Zhang, L Zheng, X Chen, WX Tong, JK Xu*, L Qin*. Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment. Bioactive Materials. 2025; 46:331-346. 🔗

  2. Jin Z, Chen J, Shan Z, et al. Prevalence, risk factors, prediction of robust callus formation and accelerated fracture healing in traumatic brain injury patients: a five-year study. Journal of Orthopaedic Translation. 2025;53:151-160. 🔗

  3. Jin Z, Chen Z, Liang T, Liu W, Shan Z, Tan D, Chen J, Hu J, Qin L, Xu J. Accelerated fracture healing accompanied with traumatic brain injury: A review of clinical studies, animal models and potential mechanisms. Journal of Orthopaedic Translation. 2025; 50:71-84. 🔗

  4. Wang H, Li Y, Li H, Yan X, Jiang Z, Feng L, Hu W, Fan Y, Lin S*, Li G*. T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration. Journal of Orthopaedic Translation. 2025;51:82-93. 🔗

  5. Palanisamy P, Chow SKH, Li S, Li MMC, Cheung WH, Qin L, Zheng YP*. Establishment of subtrochanteric fracture in pre-clinical animal model. Orthopaedic Surgery. 2025. 17(9): 2726–2734. 🔗

  6. Xiaoting Zhang, Boguang Yang, Lu Feng, Xiayi Xu, Chenmin Wang, Yuk-wai Lee, Ming Wang, Xuan Lu, Ling Qin, Sien Lin*, Liming Bian*, Gang Li*. Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment. Bioactive Materials. 2024; 41:440-454. 🔗

  7. Guo JX, Yao H, Chang L, Zhu WY, Zhang YT, Li X, Yang BG, Dai BY, Chen ZY, Li Y, Zheng LZ, Tong WX, Su YX, Qin L*, Xu JK*. Magnesium Nanocomposite Hydrogel Reverses the Pathologies to Enhance Mandible Regeneration. Advanced Materials. 2024; 37(2): 2312920.  🔗

  8. Li X, Liang TZ, Dai BY, Chang L, Zhang Y, Hu SW, Guo JX, Xu SX, Zheng LZ, Yao H, Nie Y, Lian H, Li Y, He X, Yao Z, Tong WX, Wang XL, Chow DHK, Xu JK*, Qin L*. Excess glucocorticoids inhibit murine bone turnover via modulating the immunometabolism of the skeletal microenvironment. The Journal of Clinical Investigation. 2024; 134(10):e166795.🔗

  9. Xu SX, Zhang YT, Dai BY, Rao JC, Deng FY, Zhang SA, Shao HW, Li X, Jin ZY, Liang TZ, Yang YK, Li YC, Chen ZY, Tong WX, Xu JK*, Ning CQ*, Qin L*. Green-Prepared Magnesium Silicate Sprays Enhance the Repair of Burn-Skin Wound and Appendages Regeneration in Rats and Minipigs. Advanced Functional Materials. 2024; 34, 2307439. 🔗

  10. Li Z, Yang B, Yang Z, Xie X, Guo Z, Zhao J, Wang R, Fu H, Zhao P, Zhao X, Chen G, Li G*, Wei F*, Bian L*. Supramolecular Hydrogel with Ultra-Rapid Cell-Mediated Network Adaptation for Enhancing Cellular Metabolic Energetics and Tissue Regeneration. Advanced Materials. 2024; 36(15):e2307176. 🔗

  11. Huo, M, He, S, Zhang, Y, Liu, Q, Liu, M, Zhou, G, Zhou, P & Lu, J*. Mechano-driven intervertebral bone bridging via oriented mechanical stimulus in a twist metamaterial cage: An in silico study, Computers in Biology and Medicine. 2024; vol. 171, 108149. 🔗

  12. Zhang Q, Chen Z, Peng Y, Jin Z, and Qin L*. The novel magnesium-titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: Biomechanical evaluation. Journal of Orthopaedic Translation. 2023; 42:127-36. 🔗

  13. Hongri Wu, Jiulin Tan, Dong Sun, Xiaohua Wang, Jie Shen, Shulin Wang, Qijie Dai, Zhiyuan Wei, Gang Li, Sien Lin*, Fei Luo*, Zhao Xie*. Discovery of multipotent progenitor cells from human induced membrane: Equivalent to periosteum-derived stem cells in bone regeneration. Journal of Orthopaedic Translation. 2023. 42: 82-93. 🔗

  14. Zhao PC, Guo JX, Jiang TS, Xu XY, Chen SR, Li Z, Xu JK*, Li G*, Bian LM*. Vacuolated Coacervate Mediates the Bimodal Release Kinetics of Diverse Macromolecular Drugs In Vivo. Materials Today. 2023; 66: 26-35. 🔗

  15. Wang H, Lin S, Feng L, Huang B, Lu X, Yang Z, Jiang Z, Li YC, Zhang X, Wang M, Wang B, Kong L, Pan Q, Bai S, Li Y, Yang Y, Lee WYW, Currie PD, Lin C, Jiang Y, Chen J, Tortorella MD*, Li H*, Li G*. Low-Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T-Cell Effector Immunity. Advanced Science. 2023; 8:e2300989.  🔗

  16. Xie X, Li Z, Yang X, Yang B, Zong Z, Wang X, Duan L, Lin S*, Li G*, Bian L*. Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration. JACS. 2023;145(28):15218-15229. 🔗

  17. Jie Mi, Jiankun Xu, Zhi Yao, Hao Yao, Ye Li, Xuan He, Bing-Yang Dai, Li Zou, Wenxue Tong, Xiaotian Zhang, Peijie Hu,Ye Chun Ruan, Ning Tang, Xia Guo, Jie Zhao*, JuFang He*, Ling Qin*. Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene-Related Peptide. Advanced Science. 2022; 9(1), 2103005.  🔗

  18. Xu Li, Bingyang Dai, Jiaxin Guo, Yuwei Zhu, Jiankun Xu, Shunxiang Xu, Zhi Yao, Liang Chang, Ye Li, Xuan He, Dick Ho Kiu Chow, Shian Zhang, Hao Yao, Wenxue Tong, To Ngai*, Ling Qin*. Biosynthesized Bandages Carrying Magnesium Oxide Nanoparticles Induce Cortical Bone Formation by Modulating Endogenous Periosteal Cells. ACS Nano. 2022; 16:18071–18089. 🔗

  19. Yingrui Deng, Rui Li, Haixing Wang, Boguang Yang, Peng Shi, Yuan Zhang, Qiang Yang*, Gang Li*, Liming Bian*. Biomaterial-mediated presentation of Jagged-1 mimetic ligand enhances cellular activation of Notch signaling and bone regeneration. ACS Nano. 2022; 16, 1, 1051–1062. 🔗

  20. Zhuo Li, Haixing Wang, Kunyu Zhang, Boguang Yang, Xian Xie, Zhengmeng Yang, Lingchi Kong, Peng Shi, Yuan Zhang, Yi-Ping Ho, Zhi-Yong Zhang*,Gang Li*, Liming Bian*. Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration. Bioactive Materials. 2022; 13: 9-22. 🔗

  21. Yang YK, Li YC, Pan Q, Wang HX, Bai SS, Pan XH*, Ling KKS*, Li G*. Tibial cortex transverse transport accelerates wound healing via enhanced angiogenesis and immunomodulation. Bone and Joint Research. 2022. 11(4):189–199. 🔗

  22. Yang Z, Feng L, Wang M, Li Y, Bai S, Lu X, Wang H, Zhang X, Wang Y, Lin S, Tortorella MD*, Li G*. Sesamin promotes osteoporotic fracture healing by activating chondrogenesis and angiogenesis pathways. Nutrients. 2022; 14(10), 2106. 🔗

  23. Yang Z, Feng L, Wang H, Li Y, Lo JHT, Zhang X, LLu X, Wang Y, Lin S, Tortorella MD*, Li G*. DANCR Mediates the Rescuing Effects of Sesamin on Postmenopausal Osteoporosis Treatment via Orchestrating Osteogenesis and Osteoclastogenesis. Nutrients. 2021; 13(12), 4455. 🔗​

03. 

Cellular & Molecular Mechanisms

Investigations that elucidate the cellular behaviors and molecular pathways underlying musculoskeletal development, pathology, and repair.

實驗人員

  1. An Y, Zheng L, Zhang S, Zhang H, Zhang Y, Shao H, Tong W, Chen Z, Yao H, Wen Z, Xu S, Li Y, Tian Q, Cheng L, Sun W, Qin L, Xu J. Hydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis. Biomaterials. 2025. 323:123428. 🔗

  2. Li Z, Guo Z, Yang Z, Yang B, Hu Y, Xie X, Zong Z, Chen Z, Zhang K, Zhao P, Li G*, Yang X*, Bian L*. Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration. Cell Reports. 2025. 44(5):115611. 🔗

  3. Xie X, Li T, Ma L, Wu J, Qi Y, Yang B, Li Z, Yang Z, Zhang K, Chu Z, Ngai T, Xia J, Wang Y*, Zhao P*, Bian L*. A designer minimalistic model parallels the phase-separation-mediated assembly and biophysical cues of extracellular matrix. Nature Chemistry. 2025. 17, 1216–1226. 🔗

  4. Yang Z, Hou N, Cheng W, Lu X, Wang M, Bai S, Lin Y, Wang Y, Lin S, Zhang P, Tortorella MD*, Feng L*, Li G*. MiR-378 exaggerates angiogenesis and bone erosion in collagen-induced arthritis mice by regulating endoplasmic reticulum stress. Cell Death Dis. 2024. 15(12):910. 🔗

  5. Ma, X., Xu, R., Chen, J., Wang, S., Hu, P., Wu, Y., Que, Y., Du, W., Cai, X., Chen, H., Guo, J., Li, T. C. & Ruan, Y. C*. The epithelial Na(+) channel (ENaC) in ovarian granulosa cells modulates Ca(2+) mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility. Cell Commun Signal. 2024. 22, 398. 🔗

  6. Hou Y, Gao W, Lui KO*. A hidden role of Th17 cells in doxorubicin-induced cardiac ferroptosis. Cardiovascular Research. 2024. 120:1989-1991. 🔗

  7. Lui KO*, Ma Z, Dimmeler S*. SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects? Cardiovascular Research. 2024. 120(1):34-43. 🔗

  8. Yang KY, Liao J, Ma Z, Tse HF, Lu L, Graca L, Lui KO*. Single-cell transcriptomics of Treg reveals hallmarks and trajectories of immunological aging. Journal of Leukocyte Biology. 2024. 115:19-35. 🔗

  9. Peng X, Li Y, Liu M, Li Z, Wang X, Zhang K*, Zhao X*, Li G*, Bian L*. Complex coacervate-derived hydrogel with asymmetric and reversible wet bioadhesion for preventing UV light-induced morbidities. Bioactive Materials. 2023. 30:62-72. 🔗

  10. Li X, Ma Z, Lui KO*. A differentiation protocol for the generation of pancreatic beta-like cells from human embryonic stem cells. STAR Protocol. 2023. 4:102407. 🔗

  11. Ma Z, Sugimura R*, Lui KO*. The role of m6A mRNA modification in normal and malignant hematopoiesis. Journal of Leukocyte Biology. 2023. 115:100-115. 🔗

  12. Bingyang Dai, Jiankun Xu, Xu Li, Le Huang, Chelsea Hopkins, Honglian Wang, Hao Yao, Jie Mi, Lizhen Zheng, Jiali Wang, Wenxue Tong, Dick Ho-kiu Chow, Ye Li, Xuan He, Peijie Hu, Ziyi Chen, Haiyue Zu, Yixuan Li, Yao Yao, Qing Jiang & Ling Qin*. Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis. Nature Communications. 2022. 13, 427. 🔗

  13. Liu D, Yang KY, Chan VW, Ye W, Chong CCN, Wang CC, Wang H, Zhou B, Cheng KKY, Lui KO*. YY1 regulates glucose homeostasis through controlling insulin transcription in pancreatic beta cells. Diabetes. 2022. 71:961-977.​ 🔗

  14. Ma Z, Li X, Fan RLY, Yang KY, Ng CSH, Lau RWH, Wong RHL, Ng KK, Wang CC, Ye P, Fu Z, Chin AWH, Lai MYA, Huang Y, Tian XY, Poon LLM*, Lui KO*. A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4. Stem Cell Reports. 2022. 17:538-555. 🔗

  15. Lui KO*, Huang Y. PHB2 Governs Metabolism and Phenotypic Switching of VSMCs in Vascular Remodeling. Circulation Research. 2022. 131:825-827. 🔗

  16. Peng Ye, Zelong Fu, Jeff Yat-Fai Chung, Xiaoyun Cao, Ho Ko, Xiaoyu Tian, Patrick Ming-Kuen Tang, Kathy Lui*. Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis. Front Cardiovasc Med. 2022. 8:810477. 🔗

  17. Wang B, Pang MR, Song YC, Wang HX, Pan Q, Bai SS, Lei XX, Wei SK, Zong ZX, Lin SE, Cen XT, Tortorella M, Zhang XT, Wang X, Yang YK, Li Y, Wang Y, Xu HJ, Hang L, Cheng B, Lee YK, Qin DJ*, Li G*. Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat-shock protein family. Bioengineering & Translational Medicine. 2022. e10354. 🔗​

  18. Xiaona Chen, Jie Yuan, Guang Xue, Silvia Campanario, Di Wang, Wen Wang, Xi Mou, Shiau Wei Liew, Mubarak Ishaq Umar, Joan Isern, Yu Zhao, Liangqiang He, Yuying Li, Xiaohua Yu, Christopher J. Mann, Lei Wang, Eusebio Perdiguero, Wei Chen, Yuanchao Xue, Yoshikuni Nagamine, Chun Kit Kwok, Hao Sun, Pura Muñoz-Cánoves, Huating Wang*. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nature Communications. 2021. 12:5043. 🔗

  19. Yile Huang, Yulong Qiao, Yu Zhao, Yuying Li, Jie Yuan, Jiajian Zhou, Hao Sun*, Huating Wang*. Large scale RNA-binding proteins/LncRNAs interaction analysis to uncover lncRNA nuclear localization mechanisms. Briefings in Bioinformatics. 2021. 22(6):1-15. 🔗

_cgi-bin_mmwebwx-bin_webwxgetmsgimg__&MsgID=8094158629117050038&skey=_crypt_6f5c9ada_41293

04. 
Biomaterials & Implant Design

Work exploring advanced biomaterials and implant engineering to improve safety, performance, and integration in orthopaedic applications.

  1. Shao H, Xu S, Zeng F, Jin Z, Ji X, Shan Z, Kang J, Tian Q, Zhang S, Mao X, Zhang Y, Xu J, Tong W*, Qin L*. Metal–organic framework-integrated nanoplatform orchestrates osteochondral-synovial homeostasis for osteoarthritis therapy. ACS Nano. 2025. 19 (36):32744-32766. 🔗

  2. He Y, Han Y, Yu Z, Wang W, Chen S, Osman A, Liang Z, Mao Z, Chen Z, Li Y, Lu J*. Multifunctional origami magnetic-responsive soft actuators with modular designs. Journal of Materials Science & Technology. 232:103-114. 🔗

  3. Zhou L, Zhang J, Feng G, Chen Y, Xie Y, Zhang J, Li G, Zhou T, Zhou Y, Duan F, Luan H, Chen A, Guo C, Yang T, Lu J*. Homogenization of AlCoCrFeNi2.1 eutectic high entropy with improved corrosion resistance fabricated by selective laser melting. Corrosion Science. 2025. 255:113141. 🔗

  4. Zhou L, Duan F, Zhou Y, Bai X, Jiang Z, Zhou T, Li Q, Luan H, Li G, Luan J, Chen X, Chen A, Li Y, Wang X, Yang T, Lu J*. Nanotwinned precipitates induced ultra-strong AlCoCrFeNi2.1 eutectic high-entropy alloy through additive manufacturing. Materials Today. 2025. 88:99-108. 🔗

  5. Guo C, Wang J, Lu H, Wang Y, Bai J, Li G, Yin Y, Yao L, Zhu Q*, Lu J*. Enhanced oxidation resistance of additively manufactured Inconel 718 superalloy by surface mechanical attrition treatment. Corrosion Science. 2025. 246:112719. 🔗

  6. Chen A, Su J, Zhou M, Cang M, Li, Y, Shi Y, Zhang Z, Zhu Y, Su B, Liu Y, Ye ZG, Shi Y, Röedel J, Cui H, Zhang H*, Zhou K*, Lu J*, Yan C*. Biocompatible piezoelectric lattice materials with ultrasound-regulated multimodal responses. Mater Sci Eng R Rep. 2025. 162:100876. ​🔗

  7. Zhang H#, Chen X#, Ong MTY, Lei L, Zheng L, Dai B, Tong W, Fu BSC, Xu J*, Yung PSH*, Qin L*. Current advances of artificial ligaments for anterior cruciate ligament reconstruction. Engineering. 2025. 46:47–59. 🔗

  8. Zhang NZ, Zhang QD, Shao HW, Shan ZM, Xu JK, Tong WX, Wong RMY*, Qin L*. Magnesium as an emerging bioactive material for orthopedic applications: bedside needs lead the way from innovation to clinical translation, Regen Biomater. 2025. 12:rbaf032. 🔗

  9. Zu H#, Zheng L#, Huo M, Liu K, Dreyer CH, Zhang Y,  He X, Li Y, Zou L, Huang L, Yi X, Sun AR, Meng M, Shi K, Cao H, Zu X, Tong W, Chow DH, Wang X, Lai Y, Xu J, Ding M, Lu J, Qin L*. Tree-inspired magnesium hybrid column for preventing hip collapse in steroid-associated osteonecrosis in bipedal emus. Mater Today. 2024. 80:113–138. 🔗

  10. Zhong S, Zhang L, Li Y, Chen X, Chai S, Li G, Liu H, Guo C, Wang X, Zhang D, Lu J*. Superelastic and robust NiTi alloys with hierarchical microstructures by laser powder bed fusion. Additive Manufacturing. 2024. 90:104319. 🔗

  11. Liu H, Yu H, Guo C, Chen X, Zhong S, Zhou L, Osman A, Lu J*. Review on fatigue of additive manufactured metallic alloys: microstructure, performance, enhancement, and assessment methods. Adv Mater. 2024. 36(17):2306570. 🔗

  12. Guo C, Xu Z, Li G, Wang J, Hu X, Li Y, Chen X, Liu H, Cheng L, Zhong S, Zhu Q*, Lu J*. Printability, microstructures and mechanical properties of a novel Co-based superalloy fabricated via laser powder bed fusion. J Mater Sci Technol. 2024. 189:96–109. 🔗

  13. Liu G, Lu X, Zhang X, Zhao Y, Yi S, Xu J, Zhan Y, Yin J, Feng C, Zhou Z, Wang P, Chen Z, He Y, Chen S, Liu P, Zuo J, Da, Y, Wu J, Liu S, Lu J*. 3D/4D additive–subtractive manufacturing of heterogeneous ceramics. J Mater Sci Technol. 2024. 201:210–221. 🔗

  14. Lu X, Liu G, Lu J*. Development of Ceramic 3D/4D Printing in China. Additive Manufacturing Frontiers. 2024. 3(4):200158. 🔗

  15. Zhang Q*, Chen Z, Peng Y, Jin Z, and Qin L*. The novel magnesium-titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: Biomechanical evaluation. Journal of Orthopaedic Translation. 2023. 42:127-36. 🔗

  16. Zhu Y, Guo J, Sheng Y, Xu J, Qin L*, Ngai T*. Injectable magnesium oxychloride cement foam–derived scaffold for augmenting osteoporotic defect repair. J Colloid Interface Sci. 2023. 640:199–210. 🔗

  17. Zhu Y, Dai B, Li X, Liu W, Wang J, Xu J*, Xu S, He X, Zhang S, Li Q, Qin L*, Ngai T*. Periosteum-Inspired Membranes Integrated with Bioactive Magnesium Oxychloride Ceramic Nanoneedles for Guided Bone Regeneration. ACS Appl Mater Interfaces. 2022. 14:39830–39842. 🔗

  18. Zhu Y, Zhou J, Dai B, Liu W, Wang J, Li Q, Wang J*, Zhao L*, Ngai T*. A bilayer membrane doped with struvite nanowires for guided bone regeneration. Adv Healthcare Mater. 2022. 11:2201679. 🔗

05. 
Cartilage Repair & Osteoarthritis

Research examining cartilage injury, degenerative joint disease, and interventions aimed at restoring joint structure and function.

沃克的人

  1. Lei L, Wen Z, Zhang X, Zhang H, Luo Y, Guo J, Cao M, Yao H, Fu BSC, Tong W, Ling SKK, Wang J, Qin L, Xu J*, Yung PSH*. GsMTx4-loaded GelMA promotes tendon regeneration and suppresses heterotopic ossification via the Apelin signaling pathway. Biomaterials. 2025. 324:123507. 🔗

  2. Wang R, Mehrjou B, Dehghan-Banian D, Wang BYH, Li Q, Deng S, Liu C, Zhang Z, Zhu Y, Wang H, Li D, Lu X, Cheng JCY, Ong MTY, Chan HF, Li G*, Chu PK*, Lee WYW*. Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis. Arthritis Rheumatol. 2025,77(3):283-297. 🔗

  3. Zhou L, Xu J, Schwab A, Tong W, Xu J, Zheng L, Li Y, Li Z, Xu S, Chen Z, Zou L, Zhao X, Osch G*, Wen C*, Qin L*. Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair. Bioact Mater. 2023. 26:490–512. 🔗

  4. Dai B, Zhu Y, Li X, Liang Z, Xu S, Zhang S, Zhang Z, Bai S, Tong W, Cao M, Li Y, Zhu X, Liu W, Zhang Y, Chang L, Yung PSH, Ho KKW, Xu J*, Ngai T*, Qin L*. Blockage of Osteopontin-Integrin β3 signaling attenuates osteoarthritis in mice. Adv Sci. 2023. 10(22):2300897. 🔗

  5. Li Y, Li L, Wang M, Yang B, Huang B, Bai S, Zhang X, Hou N, Wang H, Yang Z, Tang C, Li Y, Lee WYW, Feng L*, Tortorella MD*, Li G*. O-alg-THAM/gel hydrogels functionalized with engineered microspheres recruit endogenous stem cells for cartilage repair. Bioact Mater. 2023. 28:255–272. 🔗

  6. Li Y, Li L, Li Y, Feng L, Wang B, Wang M, Wang H, Zhu M, Yang Y, Waldorff EI, Zhang N, Viohl I, Lin S, Bian L, Lee WWY*, Li G*. Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field. Bioact Mater. 2023. 22:312–324. 🔗

  7. Feng L, Yang ZM, Li YC, Pan Q, Zhang XT, Wu XM, Lo JHT, Wang HX, Bai SS, Lu X, Wang M, Lin SE, Pan XH*, Li G*. MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and BMSC chondrogenesis. Mol Ther Nucleic Acids. 2022. 28:328–341. 🔗

  8. Feng L, Yang Z, Li Y, Hou N, Yang B, Lu X, Bai S, Wang M, Zhang X, Wang H, Wang Y, Tortorella MD*, Li G*. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022. 154:113608. 🔗

  9. Wang M, Li Y*, Feng L, Zhang X, Wang H, Zhang N, Viohl I, Li G*. Pulsed electromagnetic field enhances healing of a meniscal tear and mitigates posttraumatic osteoarthritis in a rat model. Am J Sports Med. 2022. 50(10):2722–2732. 🔗

脊柱模型顯示

06. 
Spine & Intervertebral Disc Regeneration

Studies on spinal disorders and disc degeneration, with an emphasis on therapeutic strategies to restore structural integrity and biomechanical function.

  1. Lin Y, Jiang Z, Yang J, Wang M, Zhang X, Lu X, Bai S, Liang T, Li B, Shao J, Zhang L, Gao D, Chen J, Lin S*, Yang F*, Li G*. Development of a standardized and reproducible murine femoral distraction osteogenesis model. J Orthop Translat. 2024. 49:74–81. 🔗

  2. Huo M, He S*, Zhang Y, Liu Q, Liu M, Zhou G, Zhou P, Lu J*. Mechano-driven intervertebral bone bridging via oriented mechanical stimulus in a twist metamaterial cage: An in silico study. Comput Biol Med. 2024. 171:108149. 🔗

  3. Wei Z, Zhou J, Shen J, Sun D, Gao T, Liu Q, Wu H, Wang X, Wang S, Xiao S, Han C, Yang D, Dong H, Wu Y, Zhang Y, Xu S, Wang X, Luo J, Dai Q, Zhu J, Lin S*, Luo F*, Tian Y*, Xie Z*. Osteostaticytes: A novel osteoclast subset couples bone resorption and bone formation. J Orthop Translat. 2024. 47:144-160. 🔗

07.  
Neuro-Musculoskeletal Interface

Investigations focusing on the interactions between the nervous system and musculoskeletal tissues, particularly in injury, regeneration, and functional restoration.

數位腦機介面

  1. Lu X, Bai S, Feng L, Yan X, Lin Y, Huang J, Liao X, Wang H, Li L, Yang Z, Yan LYC, Yang B, Wang M, Jin J, Zong Z, Jiang Z, Huang C, Liu C, Zhang X, Su H, Wang Y, Lee WY, Jiang X, Tortorella MD, Lin S, Ko H*, Li G*. Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function. Alzheimers Dement. 2025. 21(2):e14518. 🔗

  2. Cui C, Hu Y, Wong RMY, Zhang N, Guan Y, Cheung WH*. Exploring motor unit and neuromuscular junction dysfunction in aging and sarcopenia: insights from electromyography in systematic review. GeroScience. 2025. 🔗

  3. Cui C, Bao Z, Chow SK, Wang Q, Chai S, Xu Z, Jiang Q*, Cheung WH*. An Optimized Ex Vivo Protocol for Quantitative Electrophysiological Assessment of Neuromuscular Junctions and Skeletal Muscle Function Using the Aurora System. Bio Protoc. 2025;15(12):e5353. 🔗

  4. Bai SS, Lu X, Pan Q, Wang B, U KP, Yang YK, Wang HX, Lin SE, Feng L, Wang Y, Li YC, Lin WP, Wang YJ, Zhang XT, Li Y, Li LL, Yang ZM, Wang M, Lee WYW, Jiang XH, Li G*.Cranial bone transport promotes angiogenesis, neurogenesis, and modulates meningeal lymphatic function in middle cerebral artery occlusion rats. Stroke. 2022. 53(4):1373–1385. 🔗

協作數據分析

08. 
Clinical Translation & Regulatory Science

Work bridging laboratory innovations to clinical implementation, covering safety evaluation, regulatory pathways, translational methodologies, etc.

  1. Lu Q, Hsueh YS, Tong WX, Zhang YT, Xu JK, Qin L*. The Importance to Understand Medical Device Regulations for Accelerating Clinical Translation.  J Orthop Translat. 2025. 51:290-297. 🔗

  2. Hsueh YS, Qin L*. HK needs independent regulatory body for medical product review. China Daily. 2024. 587301. 🔗

  3. Hsueh YS, Tong WX, Lu Q, Yung PSH, Qin L*. Regulatory Initiatives: Establishing a HKFDA-like independent regulatory body for medical devices and mutual recognition mechanism, with HK and NMPA as an Example. Chinese Medical Journal.

09.  
Guidelines & Standards

Literature that informs the development of musculoskeletal-related guidelines and standards derived from this project’s research outcomes.

guideline background.jpg

  1. Lei Y#, Zhang Y#, Zhou L, Zhou Z, Rothbauer M, Bai L, Xu J, Xie D, Mobasheri A, Zhang X, Shi D, Ding C, Xu J, Huang W, Feng S, Yang L, Lai Y, Lei G, Luo Z, Li C, Su J, Hunter DJ, Chen D, Gu Z*, Qin L*, Tuan RS*, Li AZ*. Organoids and Organs-on-Chips for Accelerating R&D and Clinical Translation in Orthopaedics: Emerging Opportunities and Regulatory Pathways. Journal of Orthopaedic Translation. 2026. In Press. 🔗

  2. Zhou L, Huang J, Li C, Gu Q, Li G, Li AZ*, Xu J*, Zhou J*, Tuan RS*, Organoids and organs-on-chips: Recent advances, applications in drug development, and regulatory challenges. Med. 2025. 6(4):100667. 🔗

  3. Wang L, Tao TZ, Yang HL, Li CL, Yang NL, Cheng XG, Chen BH, Deng LF, Zhu P*, Tang PF*, Qin L*. 中國老年骨質疏鬆癥診療指南.2023. 🔗

Contact Us

Address: Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Hong Kong SAR

Tel. +852 3505 3308

Email. aoe-msk-reg@cuhk.edu.hk

Copyright © 2025. All Rights Reserved. RGC-AoE Centre of Aging in Musculoskeletal Degeneration and Regeneration, the Chinese University of Hong Kong.. 

bottom of page